50 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
University of Toronto
Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.
University of Toronto
Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET.
University of Toronto
Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.
University of Toronto
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.
University of Toronto
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
University of Toronto
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
University of Toronto
Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
University of Toronto
Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.
University of Toronto
Synthesis and in vitro evaluation of derivatives of theß¿?-adrenergic receptor antagonist HX-CH 44.
University of Toronto
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.
University of Toronto
A collection of caged compounds for probing roles of local translation in neurobiology.
University of Toronto
Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions.
University of Toronto
Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
University of Toronto
Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.
University of Toronto
Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.
University of Toronto
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
University of Toronto
Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.
University of Toronto
De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.
University of Toronto
The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.
University of Toronto
Monosaccharide inhibitors targeting carbohydrate esterase family 4 de-N-acetylases.
University of Toronto
Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
University of Toronto
Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.
University of Toronto
Noncovalent Protein Arginine Deiminase (PAD) Inhibitors Are Efficacious in Animal Models of Multiple Sclerosis.
University of Toronto
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.
University of Toronto
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
University of Toronto
Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases.
University of Toronto
Pharmacological profiles of the metabotropic glutamate receptor ligands.
University of Toronto
Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.
University of Toronto
Dopamine D2-like sites in schizophrenia, but not in Alzheimer's, Huntington's, or control brains, for [3H]benzquinoline.
University of Toronto
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
University of Toronto
Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.
University of Toronto
Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II.
University of Toronto
Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.
University of Toronto
Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
University of Toronto
The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.
University of Toronto
Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.
University of Toronto
A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
University of Toronto
pH-dependent modulation of agonist interactions with [3H]-ketanserin-labelled S2 serotonin receptors.
University of Toronto
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
University of Toronto
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
University of Toronto
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.
University of Toronto